Description

Myocil is a brand of Cilnidipine available as Myocil 5/ 10/ 20 mg tablets for the management of Hypertension along with End Organ Protection, Patient with Diabetes Mellitus, Albuminuria, and Chronic Kidney Disease.

Cilnidipine is a 4th generation dihydropyridine (DHP) type of CCB originally developed in Japan. Unlike other calcium channel antagonists, Myocil blocks the influx of Ca++ ions into both vascular smooth muscle at the level of L-type Ca channels and neuronal cells at the level of N-type Ca channels. The blockade of N-type Ca++ channels affects predominantly peripheral nerve endings of sympathetic neurons. So, Myocil reduces sympathetic over activity in addition to reducing vascular resistance (through L type Ca++ Channel blockage).